Structure of a glutamate transporter homologue from Pyrococcus horikoshii

By D. Yernool, O. Boudker, Yan-Ping Jin, Eric Gouaux. Nature, 2004

815 citations recorded by the source corpus.

Subfields: Biochemistry, Cellular and Molecular Neuroscience

View Paper: https://www.semanticscholar.org/paper/fc3ebbc55972e8c4d0b3e34007a10ef2151dd65c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. S. White
2. Yun Zhou
3. T. Kawate
4. N. Danbolt
5. Eric Gouaux

In Cellular and Molecular Neuroscience

1. S. White
2. T. Kawate
3. Yun Zhou
4. N. Danbolt
5. Eric Gouaux

Citations in the corpus

• Large-scale determination of previously unsolved protein structures using evolutionary information (2015, background): “…have been found in several transporter proteins and are frequently involved in ion binding ( Screpanti and Hunte, 2007 ); a similar arrangement of broken helices is also observed in structures of CLC chloride channels and glutamate transporter Glt ( Dutzler et al., 2002 ; Yernool et al., 2004 ).”
• Fluorescence-detection size-exclusion chromatography for precrystallization screening of integral membrane proteins. (2006, methodology): “Screening Tag Position by FSEC Using traditional approaches to precrystallization screening, we had previously obtained diffraction-quality crystals of the trimeric glutamate transporter homolog from Pyrococcus horikoshi (GltPh) expressed with a C-terminally-tagged construct (Figures 6B and 6C) ( Ye”
• Mechanisms of neurotransmitter release by amphetamines: a review. (2005, background): “The structure of the putative glutamate transporter (Yernool et al., 2004) suggested an alternate model in which coordinated ''flipper'' movements of two sets of two hairpin loops might allow alternating access by occluding the transporter, perhaps in a series of three conformations.”
• Biophysical dissection of membrane proteins (2009, methodology): “For sodium-coupled transporters, the energy gained from the movement of sodium ions down an electrochemical gradient is used to concentrate substrates, such as aspartat”
• Glutamate as a neurotransmitter in the healthy brain (2014, background): “The recent determination of the crystall structure of a glutamate transporter homologue (GltPh) from Pyrococcus horikoshii (Yernool et al. 2004) and other transporters (Penmatsa and Gouaux 2013) implies a milestone similar to the cloning of the first transporters in the early 1990s and the generatio”