Aptamers in Therapeutics.
By A. Parashar. Journal of clinical and diagnostic research : JCDR, 2016
689 citations recorded by the source corpus.
Aptamers are single strand DNA or RNA molecules, selected by an iterative process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX). Due to various advantages of aptamers such as high temperature stability, animal free, cost effective production and its high affinity and selectivity for its target make them attractive alternatives to monoclonal antibody for use in diagnostic and therapeutic purposes. Aptamer has been generated against vesicular endothelial growth factor 165 involved in age related macular degeneracy. Macugen was the first FDA approved aptamer based drug that was commercialized. Later other aptamers were also developed against blood clotting proteins, cancer proteins, antibody E, agents involved in diabetes nephropathy, autoantibodies involved in autoimmune disorders, etc. Aptamers have also been developed against viruses and could work with other antiviral agents in treating infections.
Subfields: Biomedical Engineering, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/fc1a944635f92301544c6286895aa2ba6d738d32
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Citations in the corpus
- Aptamers in the Therapeutics and Diagnostics Pipelines (2018, background): “Compared to antibodies: (i) aptamers can be produced using cell-free chemical synthesis and are therefore less expensive to manufacture on the mg scale, (ii) aptamers exhibit extremely low variability between batches and have better controlled post-production modification, (iii) are minimally immuno”
- Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. (2014, methodology): “By analogy, the conjugation of the Apt on the surface of NPs should provide steric protection similar to that conferred by PEG, sugars and cholesterol modifications [289].”