Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice.

By Hong Xiao, P. Heeringa, P. Hu, Zhi Liu, Minglang Zhao, Y. Aratani, N. Maeda, R. Falk, J. Jennette. Journal of Clinical Investigation, 2002

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Myeloperoxidase: friend and foe (2005, background): “Further evidence of the involvement of MPO-ANCA in a mouse model of vasculitis and glomerulonephritis using MPO knockout mice immunized with mouse MPO has been presented [421] (for commentary, see ref.”
Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases (2010, background): “Unlike mouse PR3-directed ANCA, antibodies directed against mouse myeloperoxidase produce small-vessel vasculitis upon injection into wild-type mice (Xiao et al., 2002; Kain et al., 2010).”
Randomized trial of plasma exchange or high-dosage methylprednisolone as adjunctive therapy for severe renal vasculitis. (2007, background): “Exclusion criteria were (1) age 18 or 80 yr; (2) inadequate contraception in women of childbearing age; (3) pregnancy; (4) previous malignancy; (5) hepatitis B antigenemia, anti– hepatitis C virus, or anti-HIV antibody; (6) other multisystem autoimmune disease; (7) circulating anti-GBM antibodies or”