Negative regulation of the Apaf-1 apoptosome by Hsp70

By Ayman Saleh, S. Srinivasula, L. Balkir, P. Robbins, E. Alnemri. Nature Cell Biology, 2000

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Cellular Stress Responses: Cell Survival and Cell Death (2010, background): “In the cytosol, these Hsps can block apoptosome formation and activation of downstream caspases through their ability to bind to cytochrome c and procaspase-3 (in the case of Hsp27) [107, 108] and procaspases -3, -7 and Apaf1 (in the case of Hsp70) [101, 113–115].”
Apoptosis and melanoma chemoresistance (2003, background): “Intrinsic apoptosis: Apaf-1/Casp9 mitochondrial pathway A landmark study from Wang’s laboratory a few years ago established a crucial role for mitochondria during apoptosis.”
`The stress of dying': the role of heat shock proteins in the regulation of apoptosis (2004, background): “…regulatory point for the anti-apoptotic effects of several Hsps. Hsp70 can inhibit the formation of a functionally competent apoptosome by directly associating with Apaf-1 to prevent the recruitment and activation of the initiator caspase pro-caspase-9 (Beere et al., 2000; Saleh et al., 2000).”