Oxidative stress regulates collagen synthesis and matrix metalloproteinase activity in cardiac fibroblasts.

By D. Siwik, P. Pagano, W. Colucci. American Journal of Physiology - Cell Physiology, 2001

644 citations recorded by the source corpus.

How researchers see this paper

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The Pathogenesis of Cardiac Fibrosis (2013, neutral): “Increased oxidative stress activates MMPs and decreases fibrillar collagen synthesis in cardiac fibroblasts [170].”
Hydrogen Peroxide: A Signaling Messenger (2006, positive): “5–5 μM H2O2 stimulates the downregulation of multiple procollagen mRNAs, the upregulation of fibronectin mRNA, and the upregulation of matrix metalloproteinase activity at 24 hr (189).”
Matrix metalloproteinase-9: Many shades of function in cardiovascular disease. (2013, background): “Siwik and colleagues showed an abundance of MMP-9 in cardiac fibroblasts during oxidative stress (112).”
Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications (2004, background): “Other MMPs, including type I collagenase, are also activated by oxidative stress, suggesting a potential role in myocardial remodelling (Siwik et al. 2001).”