Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits

By Sung-Chun Tang, T. Arumugam, Xiangru Xu, A. Cheng, Mohamed R. Mughal, D. Jo, J. Lathia, Dominic A. Siler, S. Chigurupati, Ouyang Xin and 3 more. Proceedings of the National Academy of Sciences of the United States of America, 2007

779 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/fbc9a97707611e959e36b9f333a833e5661ad475

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. T. Wyss‐Coray
2. A. Bessis

In Immunology

1. T. Wyss‐Coray
2. Guo-Yuan Yang
3. Yongting Wang
4. Jixian Wang
5. Yuanyuan Ma
6. Kurt M. Lucin

In Neurology

1. T. Wyss‐Coray
2. Guo-Yuan Yang
3. Yongting Wang
4. Jixian Wang
5. A. Bessis
6. Yuanyuan Ma
7. Kurt M. Lucin
8. David J. Loane

Citations in the corpus

• Immune activation in brain aging and neurodegeneration: too much or too little? (2009, background): “Interestingly, TLR2 and -4 are upregulated on cerebral cortical neurons in response to ischemia/reperfusion injury, and their absence protects primary neuron cultures from energy-deprivation-induced cell death (Tang et al., 2007).”
• The biphasic function of microglia in ischemic stroke (2017, positive): “Deficiency of TLR2 or TLR4 reduced TNF-a, iNOS, and COX2 production, contributing to reduced brain infarct volume and improved neurological outcome (Pradillo et al., 2009; Tang et al., 2007).”
• Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission (2011, background): “The expression of TLR4 has occasionally been detected in astrocytes and neurons under pathological conditions (62, 66).”