Cation-chloride co-transporters in neuronal communication, development and trauma.

By J. A. Payne, C. Rivera, J. Voipio, Kai Kaila. Trends in Neurosciences, 2003

859 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Spectroscopy

View Paper: https://www.semanticscholar.org/paper/fbbdbc0fc71e8bfd92ed6470a819f267a820e5a0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. M. S. Airaksinen
2. Kai Kaila
3. Lucia Wittner

In Molecular Biology

1. G. Gamba
2. C. Rivera
3. M. S. Airaksinen
4. Kai Kaila

Citations in the corpus

• Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters. (2005, background): “Family members involved in this activity are those expressed in the CNS, with particular importance on BSC2/NKCC1, KCC2, and KCC3 (274, 312).”
• NKCC1 transporter facilitates seizures in the developing brain (2005, background): “Neonates accumulate Cl − through the action of the Na + -K + -2Cl − cotransporter (NKCC1, encoded by SLC12A2”
• Perturbed Chloride Homeostasis and GABAergic Signaling in Human Temporal Lobe Epilepsy (2007, background): “Two cation-chloride cotransporters may be especially important in controlling neuro- nal Cl (Payne et al., 2003; Sipila et al., 2006): the Na-K-2Cl cotransporter NKCC1 loads neurons with Cl and favors depolarizing responses to GABA, whereas the K-Cl cotransporter KCC2 normally extrudes Cl ,…”
• Excitotoxicity: bridge to various triggers in neurodegenerative disorders. (2013, background): “Chloride homeostasis is maintained in cells by several molecular elements, including the cation-chloride co-transporters (CCCs) and Cl –HCO3 exchangers (Payne et al., 2003; Gamba, 2005).”
• Cation-chloride cotransporters and neuronal function. (2009, methodology): “Cs + blocks KCCs because the cation selectivity sequence of K-Cl cotransport is K + z Rb + z NH 4 + >> Cs + (Payne et al., 2003; Williams and Payne, 2004).”
• Expression of Distinct α Subunits of GABAA Receptor Regulates Inhibitory Synaptic Strength (2004, neutral): “An additional consideration when evaluating developmental changes of mIPSCs amplitude are possible changes in the expression of potassium/ chloride cotransporters (Payne et al. 2003; Staley and Smith 2001).”