Direct Recognition of Cytomegalovirus by Activating and Inhibitory NK Cell Receptors

By H. Arase, E. Mocarski, A. Campbell, A. Hill, L. Lanier. Science, 2002

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Controlling NK Cell Responses: Integration of Signals for Activation and Inhibition (2013, background): “Ly49H+ NK cells in C57BL/6 mice are activated by the MCMV-encoded protein m157 expressed on infected cells (35, 37).”
Phospholipase C-γ2 Is a Critical Signaling Mediator for Murine NK Cell Activating Receptors1 (2005, background): “Because spleen viral titers at this early time point of infection reflect the efficiency of NK cell lysis of MCMV-infected cells through the m157/Ly49H pathway (6, 7, 35, 36), PLC 2 most likely plays a significant role in NK cell control of viral replication by transducing Ly49H-mediated signals.”
T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. (2004, background): “…of Immunology University of Colorado Health Sciences Center, function, and major recent advances have been made in understanding their function (Arase et al., 2002; FaureNational Jewish Medical and Research Center Denver, Colorado 80206 et al., 2003; Jamieson et al., 2002; Nakamura et al.,…”
Coronavirus disease 2019 (COVID-19): current status and future perspectives (2020, background): “Lopinavir/ritonavir (Kaletra) Lopinavir/ritonavir was first known as a protease inhibitor that nterferes with the replication and synthesis of human immunodficiency virus (HIV), leading to the production of immature, nonnfectious virus particles [68 , 69] .”