Mast cells in the development of adaptive immune responses

By S. Galli, S. Nakae, M. Tsai. Nature Immunology, 2005

1,335 citations recorded by the source corpus.

Subfields: Immunology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/fb39e14f2c967e50a3b0c2349cfaf313bd309c06

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. S. Bischoff
2. C. Cayrol
3. J. Girard
4. S. Abraham
5. A. S. St. John
6. S. Wernersson
7. R. Medzhitov
8. G. Pejler

In Immunology and Allergy

1. S. Bischoff
2. S. Abraham
3. A. S. St. John
4. S. Wernersson
5. R. Medzhitov
6. G. Pejler

Citations in the corpus

• Mast Cell: A Multi-Functional Master Cell (2016, background): “In the blood vessels, increased vascular permeability leads to edema and local inflammation, which results in antigen transport to the lymph nodes (11).”
• Mast cell-orchestrated immunity to pathogens (2010, background): “Many studies have shown that de novo production of these mediators can vary greatly depending on the stimulus and the experimental condition”
• Integrated signalling pathways for mast-cell activation (2006, background): “and participate in the regulation of adaptive immune response”
• Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data (2007, background): “As a result, mast cells have been recognized in the past decade as cells that not only regulate allergy, but also many tissue functions, such as blood flow and coagulation, smooth-muscle contraction and peristalsis of the intestine, mucosal secretion, wound healing, regulation of innate and adaptive”
• Mast cell secretory granules: armed for battle (2014, background): “(PtdIns(3,4,5)P 3 ), which leads to the activation of protein kinase C (PKC) and the release of Ca from the endoplasmic reticulum (ER).”
• The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1 (2009, background): “Among these, mast cells, which are strategically positioned close to vessel walls and epithelial surfaces exposed to the environment (36), the major sites of IL-33 expression in vivo (20) may play a major role in the response to the IL-33 danger signal.”
• The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo: A Novel ‘Alarmin’? (2008, background): “Mast cells are widely recognized for their roles as effector cells in allergic disorders, but are also important as initiators and effectors of innate immunity [28], and IL-33 may turn out to be a critical activator of mast cells during innate immune response to pathogens.”
• Recognition of microorganisms and activation of the immune response (2007, background): “Mast cells are also a component of this module, although their function is not restricted to protection against parasite”
• Deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice (2009, neutral): “1994" language="eng" relation="no"> Although mast cell functions have classically been related to allergic response”