High-throughput and ultra-high-throughput screening: solution- and cell-based approaches.

By S. Sundberg. Current Opinion in Biotechnology, 2000

402 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/fb023ffa634810b17ac638c4e313a5433e8dab90

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In Biomedical Engineering

Citations in the corpus

Outlook for cellulase improvement: screening and selection strategies. (2006, methodology): “It is often implemented using 96-well microtiter plates, although some researchers are moving towards 384-well and higher density plate formats with the help of accurate, low-volume dispensing instruments (Sundberg, 2000).”
Droplet-based microfluidic platforms for the encapsulation and screening of Mammalian cells and multicellular organisms. (2008, background): “Hence, a wide range of commercially available fluorescence-based assays (Gonzalez and Negulescu, 1998; Sundberg, 2000) can potentially be performed in a high-throughput fashion.”
Ligand–receptor interaction platforms and their applications for drug discovery (2012, background): “In general, these techniques are readily amenable to automation using so-called mix and read assays for many targets, and allow straightforward miniaturization of the assays, so high throughput screening (HTS), even ultra-HTS, can be performed [50,52,56-58].”
Biosynthesis of anthraquinones in cell cultures of the Rubiaceae (2001, background): “Recently, DNA microarrays, consisting of thousands of individual gene sequences printed in a high-density array on a glass microscope slide, provide an exciting new tool for studying gene expression on a very large scale (Graves, 1999; Sundberg, 2000).”
Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications. (2010, background): “based assays received increasing interest over the last years [43, 44].”
Lab-on-a-chip: microfluidics in drug discovery (2006, methodology): “Alternatively, screening assays can be performed in a continuous manner using a flowing system that allows the analysis and isolation of compounds on a single chi”
The Use of 3-D Cultures for High-Throughput Screening: The Multicellular Spheroid Model (2004, background): “One field of research and development for HTS focuses on automation and miniaturization issues to provide ultra–high-throughput approaches.(1,2) Another field concentrates instead on the design and adaptation of novel, more complex test systems to gain deeper insight into the effects and functions o”
Microfluidic Devices for Drug Delivery Systems and Drug Screening (2018, background): “This system lowers sample and reagent consumption from the microliter to the nanoliter range and minimizes the multistep liquid handling operation [145].”
PubChem3D: Biologically relevant 3-D similarity (2011, background): “Background Recent advances in combinatorial chemistry [1-6] and high-throughput screening technology [7-17] have made the synthesis and screening of diverse chemical compounds easier, helping to create a demand in the biomedical research community for archives of publicly available screening data.”