Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy.

By Emanuela Zappia, Simona Casazza, E. Pedemonte, F. Benvenuto, I. Bonanni, E. Gerdoni, D. Giunti, A. Ceravolo, Francesco Cazzanti, F. Frassoni and 2 more. Blood, 2005

1,464 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Orthopedics and Sports Medicine

View Paper: https://www.semanticscholar.org/paper/fa998dc0c2442e1c9dc2b98351ffbb99d3f33a57

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In Cancer Research

1. M. Schwartz
2. G. Martino
3. L. Bonfanti
4. S. Pluchino
5. A. Caplan

In Genetics

1. N. Singer
2. R. Lee
3. C. Gregory
4. A. Caplan
5. Jeffrey L Spees

In Orthopedics and Sports Medicine

1. A. Caplan

Citations in the corpus

• Safety and Immunological Effects of Mesenchymal Stem Cell Transplantation in Patients With Multiple Sclerosis and Amyotrophic Lateral Sclerosis (2010, background): “In the animal model of MS, experimental autoimmune encephalomyelitis, intravenous injection of MSCs into C57BL/6J mice was shown to downregulate the clinical severity of the disease with a parallel suppression of CNS inflammation through induction of T-cell anergy and decrease of demyelination.(22-2”
• BRAIN REGENERATION IN PHYSIOLOGY AND PATHOLOGY: THE IMMUNE SIGNATURE DRIVING THERAPEUTIC PLASTICITY OF NEURAL STEM CELLS (2011, background): “, mesenchymal stem cells), endowed with negligible transdifferentiation capability, play a profitable role in CNS repair (47, 256).”
• Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. (2008, background): “Previous studies have shown that anti-IFNg can enhance GvHD ( Yang et al., 1998 ).”
• Mesenchymal Stem Cells: Mechanisms of Immunomodulation and Homing (2010, background): “It has been shown that MSC do not promote T cell apoptosis, but rather induce T cell anergy [ 7, 16 ] .”
• Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS) (2011, background): “…Pluchino et al., 2003; 2005; Einstein et al., 2006; Makar et al., 2008; Pluchino et al., 2009; Yang et al., 2009) Mesenchymal stem cells Improvement (Zappia et al., 2005; Kassis et al., 2008; Schafer et al., 2008; Bai et al., 2009; Lanza et al., 2009; Lu et al., 2009; Rafei et al., 2009; Freedman…”