Hexameric Structure and Assembly of the Interleukin-6/IL-6 α-Receptor/gp130 Complex

By M. Boulanger, D. Chow, E. Brevnova, K. Garcia. 2003

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Citations in the corpus

IL-6 in inflammation, immunity, and disease. (2014, background): “The activated IL-6 receptor complex is generated in the form of a hexameric structure comprising two molecules each of IL-6, IL-6R, and gp130 (Boulanger et al. 2003).”
Structural insights into the assembly and activation of the IL‐27 signaling complex (2022, unknown): “The three N-terminal domains of GP130 are essential for cytokine recognition and signaling (Dahmen et al , 1998; Boulanger et al , 2003b).”
Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130. (2003, background): “site I, which is located on the face of cytokine B and D helices portantly, these specificity determinants indicate the possibility of designing specific antagonists, (Boulanger et al., 2003 ).”
Interleukin-6, a Major Cytokine in the Central Nervous System (2012, background): “For IL-6 specifically, a hexamer forms (two IL-6, two IL-6R and two gp130) that can activate intracellular tyrosin-kinases such as Janus kinase (JAK) and, to a lesser extent, TYK, which, in turn, activate a number of proteins including the STAT (signal transducer and activator of transcription) fami”
The molecular details of cytokine signaling via the JAK/STAT pathway (2018, background): “, who solved the structure of IL-6 bound to the CHR of IL6Rα and the first three domains of gp130.(54) Combined with the full structure of gp130(239)”
Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex (2008, methodology): “…of gp130 in complex with IL-6 and IL-6Ra revealed that site 1 and site 2 of the cytokines engaged IL-6Ra and gp130 in a manner analogous to the hGH/EPO paradigm, but that the site 3 engaged the Ig domain to bridge two heterotrimeric complexes into a dyad-symmetric hexamer (Boulanger et al., 2003b).”
The composition and signaling of the IL-35 receptor are unconventional (2012, background): “Potential configurations of IL-35 receptors The composition of IL-35R presents a conundrum in the mode of IL-35–IL-35R interaction and assembly given the 'site 1-2-3' architectural paradigm originally established for IL-6 (ref”
Interleukin-6 Family Cytokines. (2018, background): “Subsequently, the X-ray structure of the complex of IL-6, IL-6R, and gp130 was solved by the Garcia group and revealed a hexameric assembly of two molecules of IL-6, IL-6R, and gp130, which was proposed to serve as a blueprint of the other IL-6 family cytokines (Boulanger et al. 2003).”