Melanocytes and the microphthalmia transcription factor network.

By E. Steingrímsson, Neal G. Copeland, Nancy A. Jenkins. Annual Review of Genetics, 2004

806 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/fa2c8b60c8243f189bf1e0ddaae6b42a30127cd3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Andrea Ballabio
2. L. Larue
3. I. Slaninová

In Molecular Biology

1. Dana Pe'er
2. Andrea Ballabio
3. Levi A. Garraway
4. L. Larue

Citations in the corpus

• Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. (2011, background): “Examples include very general processes such as the regulation of mitochondrial energy metabolism (1,2), peroxisomal remodeling and biogenesis (3), endoplasmic reticulum and Golgi stress responses (4–7) and more specialized processes such as maturation of melanosomes (8), exocrine granule maturation”
• An Integrated Approach to Uncover Drivers of Cancer (2010, background): “MITF is a master regulator of melanocyte development, function, and survival (Levy et al., 2006; Steingrı́msson et al., 2004), and the overexpression of MITF is known to have an adverse effect on patient survival (Garraway et al.”
• Signaling Pathways in Melanogenesis (2016, background): “LEF1, PAX3, SOX10, CREB, Onecut-2 and MITF protein itself bind to the MITF-M promoter and regulate MITF transcription [59].”
• Hypopigmenting agents: an updated review on biological, chemical and clinical aspects. (2006, background): “Decrease in the intracellular levels of tyrosinase and other melanogenic enzymes The most interesting point for this approach is Mitf (Microphthalmia-associated transcription factor; Steingrimsson et al., 2004; Vance and Goding, 2004).”
• Mitf regulation of Dia1 controls melanoma proliferation and invasiveness. (2006, background): “Mitf is also implicated in promoting differentiation and activating expression of melanogenic enzymes (Steingrimsson et al. 2004) and can induce a G1 cell cycle exit through up-regulation of the p21Cip1 and p16INK4a cyclin-dependent kinase inhibitors (Carreira et al. 2005; Loercher et al. 2005).”
• Melanocyte biology and skin pigmentation (2007, background): “This is representative of the affected cell linages, which include retinal pigment epithelial (RPE) cells ( Mitf mutations result in microphthalmia), osteoclasts (osteopetrosis is seen with certain mutant alleles in homozygotes) and mast cells (for which mutation causes severe dysfunction”