The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games

By T. Hehlgans, K. Pfeffer. Immunology, 2005

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TNF-α in promotion and progression of cancer (2006, background): “It has signalling potential both as a membrane-integrated protein and as a soluble cytokine released after proteolytic cleavage; its soluble form being a non-covalently bound trimer of 17 kDa components [1, 2].”
Tumor necrosis factor antagonist mechanisms of action: a comprehensive review. (2008, background): “However, some of these effects may be mediated by LIGHT (lymphotoxin-like inducible protein that competes with glycoprotein D for herpes simplex virus entry mediator on T cells), an alternative ligand for LTβR (Gommerman & Browning, 2003; Hehlgans & Pfeffer, 2005).”