Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

By Mathias Jucker, Lary C. Walker. Nature, 2013

1,573 citations recorded by the source corpus.

Subfields: Molecular Biology, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/f9f1339760d5f4749f051c8e0d9b39ef7b8cd577

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. T. Wyss‐Coray
2. M. Colonna
3. Henrik Zetterberg
4. Michael T. Heneka
5. K. Kowalski
6. John Hardy
7. Christian Haass
8. A. Mulak

In Neurology

1. T. Wyss‐Coray
2. M. Colonna
3. Henrik Zetterberg
4. Michael T. Heneka
5. John Hardy
6. Christian Haass

In Physiology

1. T. Wyss‐Coray
2. M. Colonna
3. Henrik Zetterberg
4. Michael T. Heneka
5. C. Lane
6. K. Kowalski
7. John Hardy
8. Jonathan M. Schott

Citations in the corpus

• TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis (2014, background): “(%) 103 (60)/69 (40) 55 (64)/31 (36) 36 (71)/15 (29) 12 (34)/23 (66) 0.”
• Mass Spectrometry and Machine Learning Reveal Determinants of Client Recognition by Antiamyloid Chaperones (2022, neutral): “heimer’s disease (AD) and Parkinson’s disease (4).”
• Fifty Shades of Brain: A Review on the Mechanical Testing and Modeling of Brain Tissue (2019, background): “inclusions in Alzheimer’s disease, -synuclein inclusions in Parkinson’s disease, and TDP-43 inclusions in amyotrophic lateral sclerosis and displays excellent agreement with the histological patterns observed in diseased human brains [87].”
• Neuroinflammation Induces Neurodegeneration (2016, background): “AD and PD pathogenesis starts from an area and progress to nearby regions over time through pathogenic protein transfer between affected cells and nearby unaffected cells [15].”
• Hallmarks of neurodegenerative diseases. (2023, neutral): “1,2,29,39,43 1–”
• Brain-Gut-Microbiota Axis in Alzheimer’s Disease (2019, background): “In vitro, the time that precedes protein aggregation can be greatly shortened by the addition of exogenous seeds.(14) Interestingly, Aβ has recently been recognized as antimicrobial peptide (AMP), a part of the innate immune system.”
• A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation. (2015, neutral): “See also Movie S7. amyloid-like aggregates are highly infectious, and once they have formed, they can seed further aggregation reactions in the same or in neighboring cells (Jucker and Walker, 2013).”
• Alzheimer's disease (2018, background): “These may be transferred trans-synaptically from one neuron to another [34].”