Applications of carbon nanotubes in drug delivery.

By A. Bianco, Kostas Kostarelos, M. Prato. Current Opinion in Chemical Biology, 2005

1,860 citations recorded by the source corpus.

The development of new and efficient drug delivery systems is of fundamental importance to improve the pharmacological profiles of many classes of therapeutic molecules. Many different types of drug delivery systems are currently available. Within the family of nanomaterials, carbon nanotubes (CNT) have emerged as a new alternative and efficient tool for transporting and translocating therapeutic molecules. CNT can be functionalised with bioactive peptides, proteins, nucleic acids and drugs, and used to deliver their cargos to cells and organs. Because functionalised CNT display low toxicity and are not immunogenic, such systems hold great potential in the field of nanobiotechnology and nanomedicine.

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Citations in the corpus

• The effect of particle design on cellular internalization pathways (2008, background): “, microemulsions (5), dendrimers (6), immunoconjugates (7)], or the synthesis of carbon nanotubes (8) and inorganic particles (9).”
• Distribution and biocompatibility studies of graphene oxide in mice after intravenous administration (2011, background): “Thus it appears that GO may be a promising candidate like fullerene (C60), carbon nanotubes (CNT), and nanodiamonds (ND) for biomedical applications [10,11,24].”
• POLYMER NANOCOMPOSITES BASED ON FUNCTIONALIZED CARBON NANOTUBES (2010, background): “SWNT Cycloaddition of azomethine ylides Peptides, Nucleic acids R-NHCH2COOH [349]”
• Basics and recent advances in peptide and protein drug delivery (2013, unknown): “Functionalized NPs have been used to deliver antibodies, active proteins and epitope peptides to the immune system [194,196].”
• Targeted Delivery of Pesticides Using Biodegradable Polymeric Nanoparticles (2013, background): “Considerable amount of work has been done to utilize them as nanocarriers for drug delivery (Bianco and Prato 2003; Bianco et al. 2005; Kam and Dai 2005).”
• Carbon nanotubes for biological and biomedical applications (2007, background): “The mechanism of uptake of this type of biomodified CNTs appears to be passive and endocytosis independent [76].”
• An Overview of the Recent Progress in the Synthesis and Applications of Carbon Nanotubes (2019, methodology): “7 kPa), using the vapor of iron pentacarbonyl as a source of metallic catalyst, Nanotubes are observed to combine and form masses of between 40 and 70 mm, above the burner (~30 milliseconds) [56].”