Toxin profile of Alexandrium catenella from the Chilean coast as determined by liquid chromatography with fluorescence detection and liquid chromatography coupled with tandem mass spectrometry
By B. Krock, C. Seguel, A. Cembella. 2007
126 citations recorded by the source corpus.
The profile of tetrahydropurine neurotoxins associated with paralytic shellfish poisoning (PSP) was determined from a Chilean strain of the marine dinoflagellate Alexandrium catenella. The toxin composition was compared with that of toxic shellfish, presumably contaminated by natural blooms of A. catenella from the same region in southern Chile. Ion pair-liquid chromatography with post-column derivatization and fluorescence detection (LC-FD) was employed for relative quantitative analysis of the toxin components, whereas unambiguous identification of the toxins was confirmed by tandem mass spectrometry (LC–MS/MS). In the dinoflagellate strain from Chile, the N-sulfocarbamoyl derivatives (C1/C2, B1) and the carbamoyl gonyautoxins GTX1/GTX4 comprise >90% of the total PSP toxin content on a molar basis. This toxin composition is consistent with that determined for A. catenella populations from the Pacific coast in the northern hemisphere. The characteristic toxin profile is also reflected in the shellfish, but with evidence of epimerization and metabolic transformations of C1 and C2 to GTX2 and GTX3, respectively. This work represents the first unequivocal identification and confirmation of such PSP toxin components from the Chilean coast.
Subfields: Environmental Chemistry, Oceanography
View Paper: https://www.semanticscholar.org/paper/f9b8d5b74254295cd51168f1556b95360793e0b6
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In Environmental Chemistry
- U. Tillmann
- A. Cembella
- U. John
- Tilman J. Alpermann
- E. Granéli
- P. J. Hansen
- J. T. Turner
- D. Anderson
In Oceanography
- U. Tillmann
- A. Cembella
- U. John
- Tilman J. Alpermann
- E. Granéli
- P. J. Hansen
- C. Gobler
- Paulo S. Salomon
Citations in the corpus
- Neurotoxic Alkaloids: Saxitoxin and Its Analogs (2010, unknown): “bahamense [47,49,75,76] [52] [80] [54] [63] [69] [9,71,72,81] [10]”
- PHENOTYPIC VARIATION AND GENOTYPIC DIVERSITY IN A PLANKTONIC POPULATION OF THE TOXIGENIC MARINE DINOFLAGELLATE ALEXANDRIUM TAMARENSE (DINOPHYCEAE) 1 (2010, background): “All isolates were confirmed to belong to Group I (Lilly et al. 2007) of the A. tamarense species complex (formerly North American ribotype) by sequencing of the D1-D2 LSU rDNA region (Scholin et al. 1994).”
- Paralytic shellfish toxins or spirolides? The role of environmental and genetic factors in toxin production of the Alexandrium ostenfeldii complex (2013, unknown): “previously published methods (Diener et al., 2006; Krock et al., 2007).”