Expression of Interleukin-18 in Human Atherosclerotic Plaques and Relation to Plaque Instability

By Z. Mallat, A. Corbaz, A. Scoazec, Sandrine Besnard, G. Lesèche, Y. Chvatchko, A. Tedgui. Circulation, 2001

650 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/f9a0a324dc91bb8d39632586ba398e029b77daf6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Tedgui
2. Z. Mallat
3. R. Medzhitov

In Molecular Biology

1. A. Tedgui
2. Z. Mallat

Citations in the corpus

• Management of diabetes and hyperglycemia in hospitals. (2004, neutral): “IL-18 has been proposed to destabilize atherosclerotic plaques, leading to acute ischemic syndromes (67).”
• Cytokines in atherosclerosis: pathogenic and regulatory pathways. (2006, background): “Activation of the inflammatory caspases requires the assembly of a unique intracellular complex, designated the inflammasome, that proceeds to cleave and activate IL-1 and IL-18 (452, 681).”
• Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases. (2018, background): “The recruitment of LDL cholesterol into the arterial wall also leads to activation of the NLRP3 inflammasome, since excess cholesterol is partially deposited as cholesterol crystals [157-158], which are fully internalized by human macrophages by phagocytosis and promote IL-1β and IL-18 generation [1”