SU6656, a Selective Src Family Kinase Inhibitor, Used To Probe Growth Factor Signaling

By R. Blake, M. Broome, Xiangdong Liu, Jianming Wu, M. Gishizky, Li Sun, S. Courtneidge. Molecular and Cellular Biology, 2000

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The hunting of the Src. (2001, background): “Inhibitors of Src and Src-family kinases have been develope”
The specificities of protein kinase inhibitors: an update. (2003, background): “The compound SU 6656 is also reported to inhibit members of the Src family of protein kinases [ 19 ].”
Src kinases as therapeutic targets for cancer (2009, background): “PD180970 and SU6656 can inhibit PY-STAT3 (705), which is a critical phosphorylated tyrosine site in STAT3”
A renaissance for SRC (2004, background): “c-SRC as a target of drug therapy After many years of fruitful investigation, c-SRC has recently become a target for drug therap”
SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. (2002, background): “In addition, they have the potential to be useful for therapeutic applications (Blake et al., 2000 and references therein).”