Use of Oral Corticosteroids and Risk of Fractures

By T. V. Staa, H. Leufkens, L. Abenhaim, B. Zhang, Chris Cooper. Journal of Bone and Mineral Research, 2005

639 citations recorded by the source corpus.

Subfields: Orthopedics and Sports Medicine, Rheumatology

View Paper: https://www.semanticscholar.org/paper/f943b28670bcf8185ee3918a54cb397a1b702799

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In Orthopedics and Sports Medicine

Citations in the corpus

UK clinical guideline for the prevention and treatment of osteoporosis (2017, background): “increase with the dose and duration of therapy [121, 122].”
Assessment of fracture risk (2005, background): “Glucocorticoids are an important cause of osteoporosis and fractures [42,43].”
Glucocorticoid-induced osteoporosis (2015, positive): “The increase in fracture risk is immediate, as early as 3 months after the initiation of therapy and reverses sharply after discontinuation of GCs. 45 This cannot be explained by BMD changes, but can be related to the added effects of GCs on bone remodelling previously uncoupled by the in ﬂ…”
Long-term proton pump inhibitor therapy and risk of hip fracture. (2006, background): “The 1-year duration was chosen because alterations in fracture risk due to the use of other medications, such as bisphosphonates, thiazide diuretics, and corticosteroids were apparent after 1 year of exposure.(25,26) Calcium absorption decreases with age while urinary calcium excretion increases.”
Pharmacokinetics and Pharmacodynamics of Systemically Administered Glucocorticoids (2005, background): “[206] Glucocorticoids act on coid dose[220] and correlates better with the daily various levels of transplant rejection.”
European guidance for the diagnosis and management of osteoporosis in postmenopausal women (2008, background): “Dose responses are also evident for glucocorticoid exposure [81], cigarette smoking [82] and alcohol intake [62].”
European guidance for the diagnosis and management of osteoporosis in postmenopausal women (2018, background): “Doseresponses are also evident for glucocorticoid exposure [93], cigarette smoking [61] and alcohol intake [60].”
Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength. (2004, background): “In support of this idea, in humans treated with glucocorticoids, the rate of fracture increases within 3 months of the initiation of therapy, even before significant loss of BMD (25, 26).”
Disorders of bone remodeling. (2011, background): “Bone loss occurs within the first several months of initiating GC treatment, and prolonged GC-based therapy leads to a significant decrease in bone mass and an increased risk of fracture (112).”