5 Mechanism and Regulation of Initiator Methionyl-tRNA Binding to Ribosomes

By A. Hinnebusch. 2000

294 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f925d36e5280702fd990179222b3263c009467fb

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In Molecular Biology

1. D. Ron
2. R. Kaufman
3. H. Harding
4. I. Novoa
5. Junying Yuan
6. Yuhong Zhang
7. Mauro Costa-Mattioli
8. Phoebe D. Lu

Citations in the corpus

• Signaling the Unfolded Protein Response from the Endoplasmic Reticulum* (2004, unknown): “a b-ZIP transcription factor required for induction of genes encoding amino-acid biosynthetic functions (35).”
• Translational control in the endoplasmic reticulum stress response. (2002, background): “Thus, phosphorylation of eIF2α turns out to be a convenient means to control translation initiation, and specific eIF2α kinases have evolved to couple upstream signals to this pivotal event (8, 9).”
• Cellular response to endoplasmic reticulum stress: a matter of life or death (2006, background): “Indeed, this mechanism is reminiscent of the upregulation of GCN4 mRNA in yeast by Gcn2p-mediated eIF2a phosphorylation.(58,59,90) Therefore, while eIF2a phosphorylation inhibits”
• Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response (2004, background): “The crucial event is the paradoxically increased translation of the GCN4 mRNA, triggered by yeast’s only eIF2 kinase, Gcn2p, which is activated by amino acid deprivation (Hinnebusch, 2000; Dever, 2002).”
• An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. (2003, background): “…cells against oxidative stress. results in reduced activity of the eIF2 complex, reduced Activation of this integrated stress response is shown rates of translation initiation, and reduced protein syn- to have a special role adapting cells to the metabolic thesis (Hinnebusch, 2000; Dever, 2002).”
• Translational control of long-lasting synaptic plasticity and memory. (2009, background): “GCN2 is the only eIF2a kinase that is evolutionarily conserved from yeast to mammals (Costa-Mattioli et al., 2007b; Hinnebusch, 2000) and is enriched in the brain of flies (Santoyo et al., 1997) and mammals (Berlanga et al., 1999; Sood et al., 2000), especially in the hippocampus (Costa-Mattioli et…”