Inflammatory bowel disease: cause and immunobiology

By Daniel C. Baumgart, Simon R. Carding. The Lancet, 2007

2,049 citations recorded by the source corpus.

Subfields: Genetics, Immunology

View Paper: https://www.semanticscholar.org/paper/f8d2225ac8d11d83993c78c263b8ce7054bfc0bf

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Beth Levine
2. DM Mosser
3. Rob Knight
4. X. Zhang

In Immunology

1. Beth Levine
2. Simon R. Carding
3. DM Mosser
4. Rob Knight
5. X. Zhang
6. V. Deretic

Citations in the corpus

• Mesenchymal Stem Cell-Derived Exosomes and Other Extracellular Vesicles as New Remedies in the Therapy of Inflammatory Diseases (2019, background): “Macrophage-derived TNF-α and IL-1β induce enhanced expression of E and P selectins on endothelial cells enabling massive influx of circulating monocytes and lymphocytes in the injured gut [22].”
• Meta-analyses of human gut microbes associated with obesity and IBD (2014, background): “Inflammatory bowel disease (IBD), which includes Crohn’s Disease and Ulcerative Colitis [33], has clearer reported taxonomic shifts than obesity, including a depletion of Firmicutes and Bacteroides and enrichment in Proteobacteria and Actinobacteria”
• Macrophage activation by endogenous danger signals (2008, background): “IBD comprises the two chronic disorders that are characterized by inflammation of the bowel: ulcerative colitis and Crohn’s disease [120].”
• The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics (2021, background): “CD mostly occurs in the small and large intestine, but it can also affect the mouth, esophagus, stomach, and anus, while CD commonly affects the colon and the rectum [42,43].”
• Dysbiosis of the gut microbiota in disease (2015, background): “Crohn’s disease (CD) and ulcerative colitis (UC) are the most prevalent forms of inflammatory bowel disease (IBD), characterised by chronic relapsing inflammation affecting the intestinal mucosa.”
• Unveiling the roles of autophagy in innate and adaptive immunity (2007, background): “The pathogenic mechanisms of Crohn's disease are poorly understood but are speculated to involve a dysregulated immune response to commensal gut bacteria and possibly defects in mucosal barrier function or bacterial clearanc”