Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

By M. Kormann, G. Hasenpusch, M. Aneja, Gabriela Nica, A. Flemmer, S. Herber-Jonat, M. Huppmann, Lauren E. Mays, M. Illenyi, A. Schams and 6 more. Nature Biotechnology, 2011

725 citations recorded by the source corpus.

Subfields: Genetics, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f876693f1052033eef93ed56e6dd886ea017c974

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In Genetics

1. Daniel G. Anderson
2. Arnab Rudra
3. Lei Miao
4. Piotr S. Kowalski

In Molecular Biology

1. K. Karikó
2. D. Weissman
3. Hiromi Muramatsu
4. Daniel G. Anderson
5. Piotr S. Kowalski
6. Arnab Rudra
7. Lei Miao
8. R. Juliano

Citations in the corpus

• mRNA-based therapeutics — developing a new class of drugs (2014, neutral): “…mRNA 16 • F irst adoptive immunotherapy with CAR mRNA 237 , 238 • Protein replacement preclinical study: nucleoside-modified mRNA corrects disease 25 • Development of TALEN mRNA for gene editing 243 Development of zinc finger mRNA for gene editing 168 First preclinical study with intranodally…”
• Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA (2011, background): “The use of mRNA has also expanded, including the delivery of mRNA to generate induced pluripotent stem (iPS) cells (1–3) and in vivo administration to express therapeutic proteins (4).”
• Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery. (2019, positive): “107 Moreover, the delivery of LNP-formulated mRNA directly into the colon was signi fi cantly augmented by ultrasound resulting in localized translation of fi re fl y luciferase protein, demonstrating the potential utility of ultrasound-mediated mRNA delivery for gastrointestinal diseases.”