Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery.
By Piotr S. Kowalski, Arnab Rudra, Lei Miao, Daniel G. Anderson. Molecular Therapy, 2019
924 citations recorded by the source corpus.
mRNA has broad potential as a therapeutic. Current clinical efforts are focused on vaccination, protein replacement therapies, and treatment of genetic diseases. The clinical translation of mRNA therapeutics has been made possible through advances in the design of mRNA manufacturing and intracellular delivery methods. However, broad application of mRNA is still limited by the need for improved delivery systems. In this review, we discuss the challenges for clinical translation of mRNA-based therapeutics, with an emphasis on recent advances in biomaterials and delivery strategies, and we present an overview of the applications of mRNA-based delivery for protein therapy, gene editing, and vaccination.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/a26e9f85282ae1328fe3b88590736e740189ede3
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In Genetics
In Molecular Biology
Citations in the corpus
- Nanoparticles in the clinic: An update (2019, background): “We point the reader to a recent review on mRNA delivery strategies where current clinical trials and delivery vehicles are a primary focus.(19) 5 | CONCLUSIONS Nanoparticle drug delivery systems offer many advantages over their free drug counterparts, can fundamentally change how therapeutics are de”