Risk stratification in the long-QT syndrome.

By P. Ellinor, D. Milan, Calum A. MacRae. New England Journal of Medicine, 2003

844 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f860bb0c800937c99bbc5c40b51f8c93c52f4f0c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. Adam P. Hill
2. C. Semsarian
3. Jamie I. Vandenberg
4. M. Perrin
5. Stefan A. Mann
6. J. Towbin
7. M. Perry
8. Ying Ke

In Molecular Biology

1. Adam P. Hill
2. Jamie I. Vandenberg
3. M. Perrin
4. Stefan A. Mann
5. M. Perry
6. Ying Ke
7. Douglas P. Zipes

Citations in the corpus

• Prevention of Torsade de Pointes in Hospital Settings (2010, neutral): “Data from ngenital LQTS studies (5,6) indicate that a QTc 500 ms is sociated with a 2- to 3-fold higher risk for TdP.”
• Long-QT syndrome: from genetics to management. (2012, background): “In 2003 data on 647 patients of known genotype indicated that life-threatening events were lower among LQT1 patients, higher among LQT2 females than LQT2 males, and higher among LQT3 males than LQT3 females (40).”
• HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes: document endorsed by HRS, EHRA, and APHRS in May 2013 and by ACCF, AHA, PACES, and AEPC in June 2013. (2013, background): “The use of provocative tests for QT measurement during change from a supine to standing position [20], in the recovery phase of exercise testing [21, 22], or during infusion of epinephrine [23, 24] has been proposed to unmask LQTS patients with normal QTc at resting ECG.”
• hERG K(+) channels: structure, function, and clinical significance. (2012, background): “There are some common features in all genotypes, for example, an early age of onset and a long baseline QT interval carry an increased risk of sudden cardiac arrest (SCA) irrespective of genotype (508).”
• HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies this document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA). (2011, background): “LQTS is more likely to express itself efore puberty in males and after puberty in females.(17,25,26) Besides age and sex, the degree of QTc prolongation is associated with likelihood of a first LQT-triggered cardiac event (syncope or aborted cardiac arrest) while occurrence of such cardiac events, p”
• 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the preventionof sudden cardiac death (2015, neutral): “Clinical, electrocardiographic and genetic parameters should be considered for the stratification of individual risk.(67) Survivors of a cardiac arrest have a high risk of recurrence, even when receiving betablockers (14% within 5 years on therapy): this evidence supports the use of ICDs in survivor”