Smooth Muscle Cell Phenotypic Transition Associated With Calcification: Upregulation of Cbfa1 and Downregulation of Smooth Muscle Lineage Markers
By Susan Steitz, Mei Y. Speer, Gabrielle Curinga, Hsueh‐Ying Yang, P. Haynes, R. Aebersold, T. Schinke, G. Karsenty, C. Giachelli. Circulation Research, 2001
857 citations recorded by the source corpus.
Subfields: Nephrology, Pulmonary and Respiratory Medicine, Rheumatology
View Paper: https://www.semanticscholar.org/paper/f85914a0da10c7dbcdfa1cdedac6d6e3be29637d
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In Pulmonary and Respiratory Medicine
Citations in the corpus
- Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality. (2003, background): “Moreover, a high PO4 concentration upregulates Cbfa1, the factor that induces the transformation of vascular smooth muscle cells to an osteoblastic phenotype [14].”
- Making or breaking the heart: from lineage determination to morphogenesis. (2006, background): “It will be interesting to determine if polymorphisms in NOTCH1 are associated with altered risk of aortic valve or even vascular calcification, given the similar osteoblast gene expression in atherosclerotic vascular smooth muscle (Steitz et al., 2001).”