Automated Three-Chambered Social Approach Task for Mice

By Mu Yang, Jill L. Silverman, Jacqueline N. Crawley. Current Protocols in Neuroscience, 2011

613 citations recorded by the source corpus.

Autism is diagnosed by three major symptom categories: unusual reciprocal social interactions, impaired communication, and repetitive behaviors with restricted interests. Direct social approach in mice has strong face validity to simple social approach behaviors in humans, which are frequently impaired in autism. This unit presents a basic protocol for a standardized, high‐throughput social approach test for assaying mouse sociability. Our automated three‐chambered social approach task quantifies direct social approach behaviors when a subject mouse is presented with the choice of spending time with either a novel mouse or a novel object. Sociability is defined as the subject mouse spending more time in the chamber containing the novel target mouse than in the chamber containing the inanimate novel object. The Basic Protocol describes procedures for testing one subject at a time in a single apparatus. A Support Protocol addresses data collection. Curr. Protoc. Neurosci. 56:8.26.1‐8.26.16. © 2011 by John Wiley & Sons, Inc.

Subfields: Cognitive Neuroscience, Molecular Biology, Social Psychology

View Paper: https://www.semanticscholar.org/paper/ff5d2c67a28194d3264a4179dde6b406d90f2ba7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

1. Mustafa Sahin
2. Court Hull
3. Wade G. Regehr

In Molecular Biology

1. Mustafa Sahin
2. Wade G. Regehr

Citations in the corpus

• Autistic-like behavior and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice (2012, positive): “Social Interaction— Animals were tested for social interaction in the three chambered apparatus (Dold Labs) as previously described 31 .”