VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism

By H. Gerber, A. K. Malik, Gregg P. Solar, D. Sherman, X. H. Liang, G. Meng, Kyu Hong, J. Marsters, N. Ferrara. Nature, 2002

755 citations recorded by the source corpus.

Subfields: Cell Biology, Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f80e0a9178d1aa7032c02d6c33922f69c0fc0654

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In Cell Biology

1. L. Claesson‐Welsh
2. D. Lyden

In Cellular and Molecular Neuroscience

1. P. Lucassen
2. R. Duman

In Molecular Biology

1. M. Shibuya
2. Shahin Rafii
3. D. Lyden
4. L. Claesson‐Welsh
5. B. Olsen
6. Kai Hu
7. M. Luisa Iruela-Arispe
8. V. Mittal

Citations in the corpus

• VEGF receptor signalling ? in control of vascular function (2006, background): “Indeed, it has been shown that survival of haematopoietic stem cells is promoted by VEGF”
• MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis. (2002, positive): “other cell types were recently reported to express VEGFR-1 (Gerber et al., 2002; Hattori et al., 2002).”
• Endothelial cells and VEGF in vascular development (2005, background): “For example, VEGF deletion in HSCs suggests an autocrine VEGF signalling loop in HSC surviva”
• Chronic stress in the adult dentate gyrus reduces cell proliferation near the vasculature and VEGF and Flk‐1 protein expression (2005, background): “Likewise, expression of VEGF and ⁄ or its receptor Flk-1 has been reported in hematopoietic stem cells (Gerber et al., 2002), retinal progenitor cells (Yang & Cepko, 1996), hippocampal”
• Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2 mediated regeneration of sinusoidal endothelial cells (2009, positive): “Indeed, the expression of VEGFR2 and VEGFR3 might not be limited to vascular cells within BM (Gerber et al., 2002; Haruta et al., 2001).”
• Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy? (2002, background): “, and by a subpopulation of haematopoietic stem cell”
• Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors (2005, background): “VEGF signaling is essential for the specification, morphogenesis, differentiation, and homeostasis of vessels (Gerber et al., 1999, 2002; Helmlinger et al., 2000; Damert et al., 2002; Ferrara et al., 2003).”
• Autocrine VEGF signaling is required for vascular homeostasis. (2007, neutral): “The concept of an autocrine signaling loop for VEGF has been previously shown in bone marrow endothelial cell progenitors (Gerber et al., 2002).”