Blood-brain barrier active efflux transporters: ATP-binding cassette gene family

By Wolfgang Löscher, Heidrun Potschka. NeuroRx, 2005

682 citations recorded by the source corpus.

Subfields: Oncology, Pediatrics, Perinatology and Child Health, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/f7fc99af6bf3f0dd27c5da54f8f3956668d8f72e

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In Oncology

1. R. Daneman

Citations in the corpus

• Modelling of the blood–brain barrier in drug discovery and development (2007, background): “The functional significance of these transporters at the BBB is complex and it has been suggested that only a luminal position confers protective efflux activit”
• The blood-brain barrier. (2015, background): “The first are efflux transporters, which are polarized to the lumenal surface and transport a wide variety of lipophilic molecules that could otherwise diffuse across the cell membrane, toward the blood (CordonCardo et al. 1989; Thiebaut et al. 1989; Loscher and Potschka 2005).”
• Penetration of Drugs through the Blood-Cerebrospinal Fluid/Blood-Brain Barrier for Treatment of Central Nervous System Infections (2010, background): “Detailed reviews on the affinities of anti-infectives and other drugs for the different transport systems located at the bloodCSF/blood-brain barrier have been reported recently (129, 149, 233).”