Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation.

By V. Richon, T. Sandhoff, R. Rifkind, PA Marks. Proceedings of the National Academy of Sciences of the United States of America, 2000

1,174 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/f7d328c4fdf7f744c5fa35bca4315faecb3ab150

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Manel Esteller
2. PA Marks
3. Ricky W. Johnstone
4. S. Ropero
5. S. Minucci
6. Pier Giuseppe Pelicci
7. Weisheng Xu
8. R. Parmigiani

In Oncology

1. A. Cano
2. Ricky W. Johnstone
3. S. Minucci
4. PA Marks
5. Pier Giuseppe Pelicci
6. M. Nieto

Citations in the corpus

• HDAC family: What are the cancer relevant targets? (2009, background): “A key player in this scenario is the induction of the cyclin dependent kinase inhibitor 1A (p21Waf1/Cip1) [95–98].”
• Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer (2006, background): “As an example, p21 (see below) is consistently upregulated by HDAC”
• Histone deacetylase inhibitors: molecular mechanisms of action (2007, background): “In preclinical studies, resistance to HDACi-induced transformed cell death was observed in human bladder carcinoma cells (T24) and prostate cancer cells (PC3) (Butler et al., 2000; Richon et al., 2000; Xu et al., 2006).”
• Histone Deacetylase Inhibitors as Anticancer Drugs (2017, background): “Its product blocks the formation of dimers from cyclins and cyclin dependent kinases (CDKs) that induce cell cycle arrest and inhibition of cell differentiation [43,44].”
• Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer (2005, background): “Certain genes with tumor suppressor–like properties, such as CDKN1A (also called p21 WAF1 ), are transcriptionally silent, without CpG island hypermethylation, in association with hypoacetylated and hypermethylated histone”
• Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice (2003, positive): “HDAC inhibitors selectively increase transcription because of the specificity of acetylation targets (Struhl, 1998; Richon et al., 2000 ).”
• Discovery and development of SAHA as an anticancer agent (2007, background): “Effect of SAHA on gene expression SAHA selectively alters the transcription of expressed genes in transformed cells ( Table 2 ) (”