Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer
By J. Hamanishi, M. Mandai, Masashi Iwasaki, Taku Okazaki, Yoshimasa Tanaka, K. Yamaguchi, T. Higuchi, H. Yagi, K. Takakura, N. Minato and 2 more. Proceedings of the National Academy of Sciences of the United States of America, 2007
1,381 citations recorded by the source corpus.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/f7c522ac1207a49af17bbb068416078338fc42e1
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
In Oncology
- Lieping Chen
- G. Freeman
- Arlene H. Sharpe
- W. Zou
- G. Dranoff
- I. Mellman
- Padmanee Sharma
- Razelle Kurzrock
Citations in the corpus
- PD-L1 expression in human cancers and its association with clinical outcomes (2016, neutral): “59 However, opposite results have been observed in breast cancer and merkel cell carcinoma, where tumor PD-L1 expression correlates with a better prognosis.”
- PD-L1 Expression as a Predictive Biomarker in Cancer Immunotherapy (2015, background): “Tumor PD-L1 overexpression confers a poorer prognosis across multiple tumor histologies, making therapeutic intervention on this immunomodulatory axis enticing (19, 20, 21, 22).”
- PD-1 and its ligands in tolerance and immunity. (2008, background): “In ovarian cancer, PD-L1 expression is inversely correlated with intraepithelial, but not stromal, infiltrating CD8 T cells, suggesting that PD-L1 inhibits the intratumor migration of CD8 T cells (124).”
- Prognostic Significance of Tumor-infiltrating T-cells in Ovarian Cancer: a Meta-analysis (2011, result): “Examining the funnel plot (Figure 3) however demonstrated evidence of asymmetry around the value of the pooled HR, but mostly due to one study with both large estimated hazard ratio and standard error [25].”
- IFN-γ from lymphocytes induces PD-L1 expression and promotes progression of ovarian cancer (2015, methodology): “However, we have reported that PD-L1 protein expression in ovarian cancer is positive in 68–69% of the cases using immunohistochemistry (Hamanishi et al, 2007; Abiko et al, 2013).”
- Inhibitory B7-family molecules in the tumour microenvironment (2008, background): “Some reports have shown that B7-H1 expression on tumour cells might also be associated with decreased numbers of tumour-infiltrating lymphocytes in patients with cance”