Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report

By J. Nicoll, D. Wilkinson, C. Holmes, P. Steart, H. Markham, R. Weller. Nature Medicine, 2003

1,464 citations recorded by the source corpus.

Subfields: Molecular Biology, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/f7bcb7e535c6bbd535a6f245d1509fd98e426b20

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. D. Selkoe
2. Fred E. Cohen
3. J. Kelly
4. D. Walsh
5. C. Cunningham
6. B. de Strooper
7. David Watson
8. Christopher M. Dobson

In Neurology

1. Fred E. Cohen
2. C. Cunningham
3. D. Selkoe

In Physiology

1. D. Selkoe
2. D. Walsh
3. B. de Strooper
4. E. Karran
5. J. Kelly
6. C. Cunningham
7. M. Mercken
8. L. Mucke

Citations in the corpus

• Deciphering the molecular basis of memory failure in Alzheimer's disease. (2004, background): “cognitive decline (Hock et al., 2003; Nicoll et al., 2003; gressive forms of AD (Lemere et al., 1996; Levy-Lahad Gilman et al., 2004). et al., 1995; Rogaev et al., 1995; Scheuner et al., 1996; Sherrington et al., 1995).”
• Therapeutic approaches to protein-misfolding diseases (2003, background): “Unfortunately, active immunization of patients with Alzheimer's disease using Aβ 1–42 revealed antibodies crossing the blood–brain barrier causing meningoencephalitis-like inflammation in 4% of the trial participants, presumably originating from microglial activatio”
• The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics (2011, background): “These data also suggest that antibodies that target amyloid plaques drive an active mechanism that removes plaques from the brai”
• Microglia and neurodegeneration: The role of systemic inflammation (2013, background): “, 2008) and has lead to some significant adverse events (Nicoll et al., 2003).”
• Neuropathology and Pathogenesis of Encephalitis following Amyloid β Immunization in Alzheimer's Disease (2004, background): “ese findings, together with the maintenance of neurofibrillary tangles and neuropil threads throughout the brain, and the presence of amyloid deposits in blood vessels located in the regions with reduced and abnormally dense parenchymal βA4 amyloid deposits, are similar to those reported in the fir”