A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis.
By Masayuki Fujii, M. Shimokawa, Shoichi Date, Ai Takano, M. Matano, K. Nanki, Y. Ohta, Kohta Toshimitsu, Yoshihiro Nakazato, K. Kawasaki and 4 more. Cell Stem Cell, 2016
757 citations recorded by the source corpus.
Subfields: Cancer Research, Oncology, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/0cfde30b3fdf5f59ba2a4b8b70d8a5b47c390e77
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In Cancer Research
In Oncology
In Pathology and Forensic Medicine
Citations in the corpus
- CMScaller: an R package for consensus molecular subtyping of colorectal cancer pre-clinical models (2017, methodology): “Importantly, for both organoids and PDXs, it has been shown that the models recapitulate the heterogeneity of their original tumors 14,15,25 .”
- Organoid modeling of the tumor immune microenvironment (2018, methodology): “Such PDOs allow human in vitro immunotherapy modeling via unified culture of tumor epithelium together with their native syngeneic, autologous tumor-reactive TILs, as opposed to epithelial-only organoid models (Boj et al., 2015; Fujii et al., 2016; Sato et al., 2011; van de Wetering et al., 2015), o”
- A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity. (2018, positive): “We and others have successfully generated organoids from primary colon, prostate, and pancreatic cancers (Boj et al., 2015; Fujii et al., 2016; Gao et al., 2014; Sato et al., 2011; van de Wetering et al., 2015) and explored the potential advantages of organoid cultures in allowing functional tests…”