The gut microbiome in neurological disorders.

By J. Cryan, Kenneth J. O'Riordan, K. Sandhu, Veronica L. Peterson, Ted G. Dinan. Lancet Neurology, 2019

1,026 citations recorded by the source corpus.

Research into the role of the gut microbiome in modulating brain function has rapidly increased over the past 10 years, albeit chiefly in animal models. Increasing clinical and preclinical evidence implicates the microbiome as a possible key susceptibility factor for neurological disorders, including Alzheimer's disease, autism spectrum disorder, multiple sclerosis, Parkinson's disease, and stroke. Cross-sectional clinical studies are bolstering the concept of altered microbial composition contributing to the pathophysiology of such diseases. However, the field is nascent, and interpretation of such data is often difficult given that the composition of the microbiome is influenced by various factors such as diet and exercise. Longitudinal studies and randomised controlled trials in humans are needed to find out if targeting the microbiome can yield novel therapeutic strategies. Systems biology approaches will also be important in integrating such data with genomic and metabolomic datasets from clinical cohorts with neurological disease to help guide individual treatment selection.

Subfields: Biological Psychiatry, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/f785c3c671582c79915701fa98068ae7c0f97e1e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biological Psychiatry

1. J. Cryan
2. G. Clarke
3. Ted G. Dinan

In Molecular Biology

1. J. Cryan
2. G. Clarke
3. Ted G. Dinan
4. S. Mazmanian
5. C. Stanton
6. P. Kennedy
7. J. Foster
8. L. Rinaman

In Physiology

1. G. Clarke
2. J. Cryan

Citations in the corpus

• Short chain fatty acids: Microbial metabolites for gut-brain axis signalling. (2022, background): “Facilitated SCFA diffusion through epithelia uses transporters such as the sodium-coupled monocarboxylate transporter (SMCT1) (Miyauchi et al., 2004; Cuff and Shirazi-Beechey, 2002), and the pH dependent hydrogen-coupled monocarboxylate transporter (MCT) 1 and 4 (Keduka et al., 2013; Tamai et al.,…”
• Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders (2021, background): “The two-way communication between the gut microbiome and the brain—termed the “gut–brain axis”—is involved in neuronal development, brain function, cognitive regulation, and aging [10].”