Dysregulated pH: a perfect storm for cancer progression

By Bradley A. Webb, Michael S. Chimenti, Matthew P. Jacobson, D. Barber. Nature Reviews. Cancer, 2011

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Insight into nanoparticle cellular uptake and intracellular targeting (2014, neutral): “9) [149,150].”
The Science and Translation of Lactate Shuttle Theory. (2018, background): “However, in cancer cells pHi approximates 7.4 (Webb et al., 2011), or the pH of normal arterial blood.”
A Unique pH-Dependent Recognition of Methylated Histone H3K4 by PPS and DIDO. (2017, background): “Acidic extracellular pH and elevated intracellular pH that promotes unrestricted proliferation and genomic instability are a hallmark of cancer (Webb et al., 2011).”
Drug resistance and combating drug resistance in cancer (2019, background): “of weak base anticancer drugs, which is described as “ion trapping”, and enables cancer cells to evade apoptosis([112,113]).”
Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy (2016, methodology): “In contrast, we used acidic extracellular pH, a more general hallmark of the microenvironment of most solid tumors (36, 48), as the stimulus to activate the release of small particles at tumor sites.”
Store-Operated Calcium Channels. (2015, neutral): “Acidification of the extracellular milieu commonly occurs in normal tissues during episodes of intense metabolic activity, hypoxic insults, and inflammation, as well as during neoplastic transformation where pH decline is correlated with tumor aggressiveness (185, 405).”