Differential Shedding of Transmembrane Neuregulin Isoforms by the Tumor Necrosis Factor-α-Converting Enzyme

By J. Montero, L. Yuste, Elena Díaz-Rodríguez, A. Esparís-Ogando, A. Pandiella. 2000

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ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors. (2006, background): “TGF- and neuregulin shedding induced by PMA was also lost in ADAM17 / fibroblasts (65, 74).”
Essential roles of Meltrin β (ADAM19) in heart development (2004, background): “One candidate is TACE, as it is involved in the PMA-induced cleavage of various ErbB ligands, namely, TGF-a, heparin-binding EGF (HB-EGF), and Neuregulin (Merlos-Suarez et al., 2001; Montero et al., 2000; Peschon et al., 1998; Sunnarborg et al., 2002).”
Neuregulins: functions, forms, and signaling strategies. (2003, background): “meltrin- ) have been shown capable of mediating shedding of NRGs from cultured cells [117,118], but their role in governing NRG signal production in vivo remains unknown.”