Response to Comment on "Human-Specific Gain of Function in a Developmental Enhancer"

By Shyam Prabhakar, Axel Visel, J. Akiyama, Malak Shoukry, K. Lewis, Amy Holt, I. Plajzer-Frick, Harris Morrison, David R FitzPatrick, Veena Afzal and 3 more. Science, 2009

261 citations recorded by the source corpus.

Subfields: Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3ad90fd9a4cf73b99d8157071590c825a9fd7ff7

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In Molecular Biology

1. Kevin N. Laland
2. Nicolas Galtier
3. Patricia J. Wittkopp
4. G. Kalay

Citations in the corpus

• How culture shaped the human genome: bringing genetics and the human sciences together (2010, background): “Nor is positive selection restricted to the protein-coding regions of the human genome, as adaptive regulatory variants have also been identifie”
• Cis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergence (2011, background): “Similarly, at least two and not more than 13 single-nucleotide changes are sufficient for a gain of gene expression in the limb in humans relative to chimpanzee”
• Biased gene conversion and the evolution of mammalian genomic landscapes. (2009, background): “Consistently, the functional characterization of the most promising of these fast-evolving elements was discussed in adaptive terms (114, 117).”