Mechanisms, pathophysiology, and therapy of arterial stiffness.

By Susan J. Zieman, V. Melenovský, David A. Kass. Arteriosclerosis, Thrombosis and Vascular Biology, 2005

1,787 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/f6b1187b0a74777206efa604b49b00b5767e8c58

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In Cardiology and Cardiovascular Medicine

1. James B. Strait
2. Rhian M. Touyz
3. E. Lakatta

Citations in the corpus

• The Endothelium and Its Role in Regulating Vascular Tone (2010, background): “Stiffening of the vascular wall can occur due to a reduction in NO production from endothelial cells, loss of smooth muscle tone [131], as well as degeneration of elastin fibres and increased collagen deposition in the vascular wall [132].”
• The Glymphatic System – A Beginner's Guide (2015, positive): “Aging is also accompanied by stiffening of the arterial wall leading to a reduction in arterial pulsatility, which is one of the drivers of glymphatic influx [71, 90].”
• Quarterly Focus Issue: Prevention/OutcomeClinical Research: Cardiovascular RiskPrediction of Cardiovascular Events and All-Cause Mortality With Arterial Stiffness: A Systematic Review and Meta-Analysis (2010, neutral): “The predictive value of arterial stiffness is based on its patho-physiological importance for arterial and overall CV performance (1–5).”
• Aging-associated cardiovascular changes and their relationship to heart failure (2012, background): “Microscopic Structural and Biochemical Changes Aging is associated with structural and functional changes of the arterial wall media (hypertrophy, extracellularmatrix accumulation, calciumdeposits) and the vascular endothelium (decrease in the release of vasodilators and increased synthesis of vasoc”
• Diabetes, Hypertension, and Cardiovascular Disease: Clinical Insights and Vascular Mechanisms (2017, background): “Vascular stiffening leads to widening of arterial pulse pressure and increased pulsatile shear, exacerbating endothelial dysfunction and vascular disease.(32)”
• Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure. (2009, neutral): “Stiffening of the conduit arteries increases the pulsatile component, exerting detrimental hemodynamic load on the heart, thus limiting coronary perfusion, impairing ventricular performance, and eventually exacerbating the development of heart failure (13, 181, 204).”
• The role of advanced glycation end products in progression and complications of diabetes (2008, neutral): “For example, AGE cross-linking on type I collagen and elastin leads to increased stiffness of blood vessels (11, 12).”
• Expert consensus document on arterial stiffness: methodological issues and clinical applications. (2006, neutral): “The molecular and cellular determinants of arterial stiffness have been reviewed in several publications.(24,102,109) The stiffness of the vascular wall is dependent on the relative contribution of its two predominant scaffolding proteins: collagen and elastin.”