Durum wheat genome highlights past domestication signatures and future improvement targets
By M. Maccaferri, N. Harris, Sven Twardziok, R. Pasam, H. Gundlach, M. Spannagl, D. Ormanbekova, Thomas M. Lux, Verena M. Prade, S. Milner and 58 more. Nature Genetics, 2019
604 citations recorded by the source corpus.
The domestication of wild emmer wheat led to the selection of modern durum wheat, grown mainly for pasta production. We describe the 10.45 gigabase (Gb) assembly of the genome of durum wheat cultivar Svevo. The assembly enabled genome-wide genetic diversity analyses revealing the changes imposed by thousands of years of empirical selection and breeding. Regions exhibiting strong signatures of genetic divergence associated with domestication and breeding were widespread in the genome with several major diversity losses in the pericentromeric regions. A locus on chromosome 5B carries a gene encoding a metal transporter (TdHMA3-B1) with a non-functional variant causing high accumulation of cadmium in grain. The high-cadmium allele, widespread among durum cultivars but undetected in wild emmer accessions, increased in frequency from domesticated emmer to modern durum wheat. The rapid cloning of TdHMA3-B1 rescues a wild beneficial allele and demonstrates the practical use of the Svevo genome for wheat improvement. Genome assembly of durum wheat cultivar Svevo enables genome-wide genetic diversity analyses highlighting modifications imposed by thousands of years of empirical selection and breeding.
Subfields: Agronomy and Crop Science, Plant Science
View Paper: https://www.semanticscholar.org/paper/f65bea226ccb209ee8d36dd78b2bc1ad5ab7c436
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In Agronomy and Crop Science
In Plant Science
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Citations in the corpus
- Multiple wheat genomes reveal global variation in modern breeding (2020, methodology): “We have built on the genome-sequence resources available for wheat and related species to produce ten RQAs and five scaffolded assemblies that represent hexaploid wheat lines from different regions, growth habits and breeding programs 1,11,12,18,20,49 .”