NF-κB, inflammation and metabolic disease

By R. Baker, M. Hayden, S. Ghosh. Cell Metabolism, 2011

1,793 citations recorded by the source corpus.

SUMMARY Metabolic disorders including obesity, type 2 diabetes and atherosclerosis have been viewed historically as lipid storage disorders brought about by overnutrition. It is now widely appreciated that chronic low-grade inflammation plays a key role in the initiation, propagation and development of metabolic diseases. Consistent with its central role in coordinating inflammatory responses, numerous recent studies have implicated the transcription factor NF-κB in the development of such diseases, thereby further establishing inflammation as a critical factor in their etiology and offering hope for the development of new therapeutic approaches for their treatment.

Subfields: Cancer Research, Epidemiology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/f659467c7630191e7345430976ec7d80eee8e44b

Citations in the corpus

• Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis (2016, neutral): “One important mechanistic link seems to be the capacity of lipid-laden, dysfunctional adipocytes to generate a variety of proinflammatory adipokines (eg, tumor necrosis factor), which can act locally within adipose tissue to activate macrophages and microvascular endothelium and also systemically to”