G Protein Pathways

By Susana R. Neves, Prahlad T. Ram, Ravi Iyengar. Science, 2002

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Reconstruction of cellular signalling networks and analysis of their properties (2005, background): “Signalling responses that are coupled with metabolic processes or 'intermediate phenotypes' (for example, the conversion of glycogen to glucose, or increases in cyclic-AMP concentrations in response to stimuli) can occur over a timeframe of fractions of a secon”
A genetically-encoded fluorescent sensor enables rapid and specific detection of dopamine in flies, fish, and mice (2018, background): “DNA encoding the various DA receptor subtypes (D1R-D5R) was generated using PCR amplification of the full-length human GPCR cDNAs (hORFeome database 8.1).”
The circadian clock: pacemaker and tumour suppressor (2003, background): “It also responds to polypeptide hormones and neurotransmitters through interactions with the c-AMP signalling pathwa”
G-protein-coupled receptors and cancer (2007, background): “Both α•GTPsubunits and Gβγ subunit complexes then stimulate several downstream effector”
The Heterotrimeric G-Protein Subunits GNG-1 and GNB-1 Form a Gβγ Dimer Required for Normal Female Fertility, Asexual Development, and Gα Protein Levels in Neurospora crassa (2005, background): “Multiple isoforms, including 6 G and 12 G subunits, have been identified in mammals (14, 32, 50 ).”