Voltage-gated proton channels and other proton transfer pathways.

By T. DeCoursey. Physiological Reviews, 2003

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The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. (2007, background): “Thus there is no doubt that there is a close relationship between NOX enzymes and proton channels; however, there are two different molecular interpretations: 1) NOX enzymes possess a proton channel domain, suggested to reside within the histidine-rich third transmembrane domain (55, 57, 365, 368, 5”
Myeloperoxidase: friend and foe (2005, background): “However, other studies have suggested that the H channel is separate from the NADPH oxidase [335–337].”
Expression cloning of TMEM16A as a calcium-activated chloride channel subunit (2008, background): “2 to close voltagegated proton channels, which only open when the electrochemical gradient is outward (Decoursey, 2003), yielded very small currents in the absence of external calcium (Figure 3G) but large”
The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins (2004, background): “Similar to transporters, channels allow movement of solutes down their electrochemical gradients [1, 4, 6 , 9, 10, 14, 20].”