A small RNA regulates the expression of genes involved in iron metabolism in Escherichia coli

By É. Massé, S. Gottesman. Proceedings of the National Academy of Sciences of the United States of America, 2002

1,193 citations recorded by the source corpus.

Subfields: Ecology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f5eabee387061d8e2ba997772f36c7d8f73c59de

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Ecology

1. G. Storz
2. J. Imlay
3. S. Gottesman
4. Freddy E. Escorcia
5. L. Waters
6. É. Massé
7. N. Noinaj
8. M. Guillier

In Genetics

1. G. Storz
2. S. Gottesman
3. J. Imlay
4. Freddy E. Escorcia
5. Nicholas R. De Lay
6. L. Waters
7. É. Massé
8. S. Buchanan

In Molecular Biology

1. G. Storz
2. S. Gottesman
3. J. Imlay
4. Freddy E. Escorcia
5. Nicholas R. De Lay
6. L. Waters
7. É. Massé
8. N. Noinaj

Citations in the corpus

• Regulatory RNAs in Bacteria (2009, background): “For example, the levels of the RyhB and OxyS sRNAs, respectively, are powerful indicators of the iron status and hydrogen peroxide concentration in a cell (Altuvia et al., 1997; Massé and Gottesman, 2002).”
• A genome-wide survey of sRNAs in the symbiotic nitrogen-fixing alpha-proteobacterium Sinorhizobium meliloti (2010, background): “The main mechanisms of sRNA-mediated control of gene expression are: repression [15-17] or activation of translation [18], mRNA degradation [19,20] or stabilization [21], and target mimicry [7,22].”
• Bacterial small RNA regulators: versatile roles and rapidly evolving variations. (2011, background): “…(gadX) (Opdyke et al. 2004; Tramonti et al. 2008) RyhB 90 Induced by limiting iron; Repressed by Fur Iron-sparing (sodB, sdhC, frdA, activates shiA) (Massé and Gottesman 2002; Massé et al. 2005; Prévost et al. 2007) FnrS 113 Induced under anaerobic conditions; Activated by FNR, ArcA and CRP…”
• TonB-dependent transporters: regulation, structure, and function (2010, background): “This apparent puzzle was solved when Massé and Gottesman identified a regulatory small RNA, RyhB, whose transcription is repressed by Fur and which, in turn, negatively regulates expression of numerous genes (58).”
• The Crp-Activated Small Noncoding Regulatory RNA CyaR (RyeE) Links Nutritional Status to Group Behavior (2008, background): “Overnight cultures of (A) NRD400 (yqaE-lacZ fusion), (B) NRD377 (ompX-lacZ fusion), (C) NRD399 (nadE-lacZ fusion), or (D) NRD413 (luxS-lacZ fusion) harboring pBR-plac (vector), pNRD405 (wild-type cyaR [Wt]), pNRD407 (cyaR A44T), pNRD408 (cyaR T47A), or pNRD410 (cyaR G38C G39A A40T [CyaR (38-40]) wer”
• IntaRNA: efficient prediction of bacterial sRNA targets incorporating target site accessibility and seed regions (2008, neutral): “…0.960 0.920 0.800 0.960 0.636 0.545 0.958 0.952 OxyS-fhlA Argaman and Altuvia (2000) 0.500 - 0.938 0.563 0.375 1.000 - 0.288 0.750 1.000 RyhB-sdhD Masse and Gottesman (2002) 0.588 0.882 0.794 0.824 0.794 1.000 0.909 0.403 1.000 0.794 RyhB-sodB Geissmann and Touati (2004) 1.000 1.000 1.000 1.000…”
• Toehold Switches: De-Novo-Designed Regulators of Gene Expression (2014, neutral): “(D) Endogenous and synthetic gene networks used for sensing the RyhB sRNA.”
• How do bacterial cells ensure that metalloproteins get the correct metal? (2009, background): “Fe–Fur also acts indirectly in the regulation of some genes by modulating the expression of RyhB small RNA (sRNA”
• Siderophore-Based Iron Acquisition and Pathogen Control (2007, background): “The small RNAs involved in this targeting are Fur-regulated antisense RNAs including RhyB in enteric bacteria (205), PrrF1/PrrF2 in P.”
• Coupled degradation of a small regulatory RNA and its mRNA targets in Escherichia coli. (2003, methodology): “1996) EM1055 DJ480 [MG1655 lac X174] (Massé and Gottesman 2002) EM1059 EM1055 ara714 leu Tn10 EM1055 + P1 (LMG194) EM1062 EM1055 ara714 leu EM1059 + P1 (EM1055) EM1063 EM1055 ara714 dsrA5 zed-3069 Tn10 EM1062 + P1 (DDS719)”
• The small RNA regulators of Escherichia coli: roles and mechanisms*. (2004, background): “This proved to be the case; Fur negatively regulates ryhB, and RyhB negatively regulates sdh, sodB (see Figure 1C), and other Fe-S protein operons, leading to rapid degradation of the message for these operons (61).”
• Iron‐sulphur clusters and the problem with oxygen (2006, background): “Acting as an antisense RNA, RyhB then stimulates the degradation of transcripts that encode Fe-S enzymes such as succinate dehydrogenase and NADH dehydrogenase I (Masse and Gottesman, 2002).”