Iron‐sulphur clusters and the problem with oxygen

By J. Imlay. Molecular Microbiology, 2006

675 citations recorded by the source corpus.

Subfields: Environmental Engineering, Nutrition and Dietetics, Renewable Energy, Sustainability and the Environment

View Paper: https://www.semanticscholar.org/paper/c67fc73d364587f66f3b35878a53fd5d41ded4a6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Environmental Engineering

1. J. M. Pérez de la Lastra
2. Eduardo Perez‐Lebeña
3. Erin R Green
4. G. T. Nguyen
5. Celia Andrés Juan
6. James J. Collins
7. Michael A. Kohanski
8. J. Mecsas

In Nutrition and Dietetics

1. D. Bailey
2. James J. Collins
3. Michael A. Kohanski
4. Maria Luisa Fiorello
5. D. Slade
6. M. Radman
7. J. Cobley

In Renewable Energy, Sustainability and the Environment

1. James J. Collins
2. Michael A. Kohanski
3. D. Slade
4. M. Radman

Citations in the corpus

• The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies (2021, background): “Free iron is necessary for the Fenton reaction to occur, so bacteria use a number of mechanisms to sequester it or to control its uptake in response to ROS in the environment [47].”
• Oxidative Stress Resistance in Deinococcus radiodurans (2011, background): “O2 can liberate Fe(2) from iron-sulfur clusters, which can react with H2O2 in the Fenton reaction to produce OH (267).”
• Sub-lethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesis (2010, background): “…can stimulate bacteria to produce reactive oxygen species (ROS) (Dwyer et al., 2007; Kohanski et al., 2007, 2008), which are highly deleterious molecules that can interfere with the normal functions of oxygen-respiring organisms (Brumaghim et al., 2003; Fridovich, 1978; Imlay, 2006).”
• Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance (2017, background): “Because free iron is susceptible to Fenton chemistry, bacteria utilize a number of mechanisms to sequester iron or control its uptake in response to encountering ROS in the environment (Liochev and Fridovich, 1994; Keyer and Imlay, 1996; Imlay, 2006, 2008).”
• 13 reasons why the brain is susceptible to oxidative stress (2018, background): “lytic activity of several enzymes, including aconitase, fumarase and cytochrome P450 [214].”
• A common mechanism of cellular death induced by bactericidal antibiotics. (2007, background): “The established mechanism underlying leaching of iron from iron-sulfur clusters predominantly occurs via superoxide (Imlay, 2006; Keyer and Imlay, 1996; Liochev and Fridovich, 1999), and it is well accepted that the majority of superoxide generation in E. coli occurs through oxidation of the…”