MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B

By M. Fabbri, R. Garzon, A. Cimmino, Zhongfa Liu, N. Zanesi, E. Callegari, Shujun Liu, H. Alder, S. Costinean, Cecilia Fernandez-Cymering and 8 more. Proceedings of the National Academy of Sciences of the United States of America, 2007

1,695 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f5c26121d6e50e6b86da6999617b309b58ec7101

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Citations in the corpus

MicroRNAs in development and disease. (2011, background): “On the other hand, downregulation of miR-29 contributes to tumorgenesis by derepressing the methyltransferase genes DNA (cytosine-5-)-methyltransferase 3 alpha (DNMT3A) and 3B, which invoke aberrant methylation and gene silencing (167).”
microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer (2011, background): “miR-29 can modulate the expression of DNMT-1 and 3B in leukemia and lung cancer cells (Fabbri et al., 2007; Garzon et al., 2009).”
MicroRNA (miRNA) in cancer (2015, background): “…specifically miR-29a/-b/-c was reported as an oncogene in breast cancer while the same miRNA-29 acted as a tumor-suppressor gene in lung tumors [31,32]; (ii) loss of miR-23b conferred proliferative advantage and promoted bladder cancer cell migration and invasion [33] while knocking down the…”
The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform. (2009, background): “Mir-29a has been found to be under-expressed in lung cancers; having been implicated in the modulation of methylation patterns seen in lung cancer [26].”
A decade of exploring the cancer epigenome — biological and translational implications (2011, background): “Intriguingly, downregulation of the miRNA-29 family has also been linked to overexpression of DNA methyltransferase”
MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death (2008, background): “In addition, an expression analysis of 217 Oncogene Table 1 miRNAs with relevance in cancer and cell death miRNA Normal function Cancer relevance Cell death relevance Targets References Let-7/miR-98 Upregulated late during Caenorhabditis elegans development; increased expression in differentiated ce”
Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin (2008, background): “miR-194 , and miR-132 miRNA that target DNA methyltransferases 3A and 3B and methyl CpG binding protein 2 (49, 50).”
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression (2008, background): “(41) have recently shown that the miR-29 family, via DNA methyltransferase 3A and 3B transcriptional regulation, can regulate DNA methylation (41).”
Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process (2008, background): “Interestingly it was shown that hsa-mir-29c directly targets DNA-methyl transferase 3A (DNMT3A) and 3B (DNMT3B) in lung cancer tissue [51].”