Water mediation in protein folding and molecular recognition.

By Yaakov Levy, José N. Onuchic. Annual Review of Biophysics and Biomolecular Structure, 2006

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A unified model of protein dynamics (2009, neutral): “[9]”
Enhancing structure prediction and design of soluble and membrane proteins with explicit solvent-protein interactions (2017, background): “…contribute to protein fold stability, participate to enzyme catalysis, signal transduction, and mediate protein-ligand, protein-DNA, and protein-protein recognition (Ahmad et al., 2011; Angel et al., 2009; Breiten et al., 2013; Levy and Onuchic, 2006; Nygaard et al., 2010; Papoian et al., 2004).”
Contact Potential for Structure Prediction of Proteins and Protein Complexes from Potts Model. (2018, background): “This distance range roughly corresponds to the water-mediated interactions (89), which indicates that solvent effects are better treated by the simpler AACE18 rather than by the more complicated AACE167 potential.”