Structure and function of type II restriction endonucleases.

By Alfred Pingoud, Albert Jeltsch. Nucleic Acids Research, 2001

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The enzymatic basis of processivity in λ exonuclease (2003, background): “The positively charged lysine residue is proposed to stabilize the negatively charged reaction intermediate that is thought to arise during hydrolytic cleavage of DNA as hypothesized for restriction endonucleases (16).”
NEBcutter: a program to cleave DNA with restriction enzymes (2003, background): “These enzymes recognize short DNA sequences (4–8 nucleotides) and cleave at, or close to, their recognition sites (1,2).”
Analysis of Genes and Genomes (2004, background): “Restriction endonucleases appear to function by ‘scanning’ the length of a DNA molecule by binding to it in a non-specific fashion (Pingoud and Jeltsch, 2001).”
Making the Bend: DNA Tertiary Structure and Protein-DNA Interactions (2014, background): “Encounter with the cognate sequence triggers a cooperative conversion of the non-specific to the specific complex and couples sequence recognition to catalytic cleavage [95] The DNA bound by HindIII is slightly bent by about 26° in comparison to ideal B-DNA [96] (calculated with the program CURVES [”