Structure of C3b reveals conformational changes that underlie complement activity

By B. Janssen, A. Christodoulidou, A. McCarthy, John D Lambris, P. Gros. 2006

394 citations recorded by the source corpus.

Subfields: Hematology, Immunology, Physiology

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1. Pavel V. Afonine
2. Paul D. Adams
3. Nigel W. Moriarty
4. T. C. Terwilliger
5. D. Liebschner
6. Nathaniel Echols
7. R. Grosse-Kunstleve
8. J. Headd

Citations in the corpus

• Towards automated crystallographic structure refinement with phenix.refine (2012, background): “…al., 2007), 1yi5 (Bourne et al., 2005), 2wjx (Clayton et al., 2009), 3eob (Li et al., 2009), 1av1 (Brouillette & Anantharamaiah, 1995), 3bbw (Qiu et al., 2008) and 2i07 (Janssen et al., 2006) were selected because their published R factors are much higher than expected (Urzhumtseva et al., 2009).”
• Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria (2007, background): “Recent studies have delineated the structure of C3 and C3 fragments and provided important insights into their functio”