Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors

By M. Hentzer, Hong Wu, J. B. Andersen, K. Riedel, T. B. Rasmussen, Niels Bagge, N. Kumar, M. Schembri, Zhi-jun Song, P. Kristoffersen and 8 more. EMBO Journal, 2003

1,444 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f4ed9093a6a340b96f8f9543141c67661a4192e6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. M. Givskov
2. B. Bassler

In Infectious Diseases

1. David A. Rasko
2. T. Bjarnsholt
3. P. Watnick
4. G. Donelli
5. H. Bais
6. E. Karatan
7. B. Bassler
8. Jorge M. Vivanco

In Molecular Biology

1. T. Bjarnsholt
2. M. Givskov
3. Niels Høiby
4. P. Nannipieri
5. Søren Molin
6. B. Bassler
7. P. Watnick
8. E. Karatan

Citations in the corpus

• Signals, Regulatory Networks, and Materials That Build and Break Bacterial Biofilms (2009, background): “aeruginosa in mouse models of both lung infections and foreign-body infections, further validating the promise held by these compounds (53, 130).”
• Quorum sensing: cell-to-cell communication in bacteria. (2005, background): “Similarly, purified halogenated furanones appear to attenuate virulence of bacteria in mouse models (Hentzer et al. 2003, Wu et al. 2004).”
• The Multiple Signaling Systems Regulating Virulence in Pseudomonas aeruginosa (2012, result): “This observation corroborates those obtained from microarray experiments on the effects of furanones on the AHL quorum-sensing regulon (85).”
• SPORE RELEASE IN ACROCHAETIUM SP. (RHODOPHYTA) IS BACTERIALLY CONTROLLED 1 (2007, methodology): “Halofuranones C2 [4-bro- mo-5-(bromomethylene)-3-butyl-2(5H)-furanone] and C30 [4-bromo-5-(bromomethylene)- 2(5H)-furanone] were isolated from Delisea pulchra and synthesized, respectively, as described previously (Manefield et al. 2002, Hentzer et al. 2003).”
• Antibiotic resistance of bacterial biofilms. (2010, neutral): “biofilms has been named sociomicrobiology (84).”
• Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections. (2003, methodology): “We have used this technique to demonstrate the target specificity of certain first-generation antipathogenic drugs (61).”
• Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics (2014, background): “aeruginosa biofilms exposed to furanones (308, 309).”