Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2

By J. R. Pomerening, Eduardo Sontag, J. Ferrell. Nature Cell Biology, 2003

784 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/15b59c65aa480f2f6aafb0774b5ee6bf46c4f659

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. T. Y. Tsai
2. Qiong Yang
3. J. Ferrell
4. Boris N. Kholodenko
5. N. Markevich
6. Jan B. Hoek
7. Mike Tyers
8. J. Pines

In Molecular Biology

1. Boris N. Kholodenko
2. T. Y. Tsai
3. Qiong Yang
4. J. Ferrell
5. J. Tyson
6. Béla Novák
7. N. Markevich
8. Jan B. Hoek

In Plant Science

1. T. Y. Tsai
2. Qiong Yang
3. J. Ferrell
4. Boris N. Kholodenko
5. N. Markevich
6. Jan B. Hoek
7. Mike Tyers
8. Paul Jorgensen

Citations in the corpus

• Integrative analysis of cell cycle control in budding yeast. (2004, background): “Bistability also has been confirmed recently for interphase and M-phase states of frog egg extracts (Pomerening et al., 2003; Sha et al., 2003).”
• Progressive activation of CyclinB1-Cdk1 coordinates entry to mitosis. (2010, background): “…extracts from Xenopus eggs showed that Wee1 exhibits ultrasensitivity to inactivation by CyclinB-Cdk1 (Kim and Ferrell, 2007), thereby generating bistable states of CyclinB-Cdk1 activity—i.e., either very low or fully active (Pomerening et al., 2003; Sha et al., 2003; reviewed in Lindqvist, 2009).”
• Modeling the cell cycle: why do certain circuits oscillate? (2011, positive): “Indeed, experimental studies have shown that, in Xenopus egg extracts, the CDK1/Wee1/Cdc25systemdoes respond tocyclin in ahysteretic fashion; it is easier to maintain an extract in M phase than it is to pushan interphaseextract intoMphase (Pomerening et al., 2003; Sha et al., 2003).”
• Network resilience (2020, background): “by the underlying feedback loops and ultrasensitivity [297, 280] or particular network topology [294, 301].”
• How cells coordinate growth and division. (2004, background): “The key question is how cell size, or some parameter correlated with cell size, initiates the positive feedback loop that propels cells into mitosis [131,132].”
• Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades (2004, methodology): “Hysteresis was documented in responses of signaling systems involving positive feedback loops, such as MAPK cascades and a cell cycle mitotic trigger (Bhalla et al., 2002; Pomerening et al., 2003; Sha et al., 2003).”
• Introduction to systems biology. (2007, background): “It was shown experimentally [103] that in the absence of the degradation of cyclin-B by APC the resulting network is bistable.”